You can't be any more central! The A&O Hamburg Reeperbahn is in the best location in the middle of St. Pauli. Right next to the hostel is an intra-city and underground train station and the trendy districts such as the Schanzenviertel, Altona and Hafencity. They can be easily reached by foot. The Central Station is just four intra-city train stops away.
Hamburg Hauptbahnhof railway station